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“Magic” mushrooms achieve their psychedelic effects by temporarily scrambling a brain network involved in introspective thinking like daydreaming and remembering, a new study reports. Brain scans of people who took psilocybin — the psychedelic drug in ‘shrooms — revealed that the substance causes profound and widespread temporary changes to the brain’s default mode network. These findings provide an explanation for psilocybin’s mind-bending effects, and could lay the groundwork for better understanding how the drug might be used to treat mental health conditions like depression, researchers said. “There’s a massive effect initially, and when it’s gone, a pinpoint effect remains,” said co-senior study author Dr. Nico Dosenbach, a professor of neurology with the Washington University School of Medicine in St. Louis. “That’s exactly what you’d want to see for a potential medicine.” “You wouldn’t want people’s brain networks to be obliterated for days, but you also wouldn’t want everything to snap back to the way it was immediately,” Dosenbach added in a university news release. “You want an effect that lasts long enough to make a difference.” Psilocybin showed promise as a treatment for depression in the 1950s and 1960s, but research into its potential flagged after the federal government deemed the substance an illegal drug in the late ‘60s, researchers explained in background notes. However, research efforts have revived in recent years as psilocybin has… read on > read on >