Weekly Gravy « Weekly Gravy

All Sauce from Weekly Gravy:

A Colombian family’s genetics are shining a spotlight on a gene that might help protect people from the ravages of Alzheimer’s disease. About 1,200 out of 6,000 family members carry a genetic variant called the “Paisa mutation,” which dooms them to early Alzheimer’s, researchers said. But 28 family members with the Paisa mutation dodged early Alzheimer’s, apparently because they carry another gene that protects against the degenerative brain disease, researchers reported June 20 in the New England Journal of Medicine. The study represents the first evidence that having this other gene — known as the “Christchurch variant” — might confer some protection against inherited Alzheimer’s, researchers said. Drugs and therapies focusing on this genetic pathway might be capable of preventing or treating dementia and Alzheimer’s in others, said co-lead author Yakeel Quiroz, director of the Familial Dementia Neuroimaging Lab at Massachusetts General Hospital. “As a clinician, I am highly encouraged by our findings, as they suggest the potential for delaying cognitive decline and dementia in older individuals,” Quiroz said in a hospital news release. “Now we must leverage this new knowledge to develop effective treatments for dementia prevention.” The study focused on variants of the apolipoprotein E (APOE) gene. The APOE4 variant is known to increase the risk of Alzheimer’s, and is linked to developing a more severe form of dementia, according to the Mayo… read on > read on >

If you’ve recovered from lower back pain, try walking away from a recurrence. New research out of Australia shows that folks who started a walking regimen kept recurrent back pain episodes at bay for much longer than people who didn’t. “We don’t know exactly why walking is so good for preventing back pain, but it is likely to include the combination of the gentle oscillatory movements, loading and strengthening the spinal structures and muscles, relaxation and stress relief, and release of ‘feel-good’ endorphins,” said senior study author Mark Hancock. He’s a professor of physiotherapy at Macquarie University in Sydney. Over 800 million people around the world suffer from low back pain, according to background information from the study authors. In 7 of 10 cases, the pain will ease — only to return later. Special exercise programs, along with educating patients about back pain, are typically part of standard care aimed at preventing a recurrence. Hancock’s team wondered if plain old walking might help. “Walking is a low-cost, widely accessible and simple exercise that almost anyone can engage in, regardless of geographic location, age or socio-economic status,” he reasoned in a Macquarie news release. In the new trial, 701 adults who had recently recovered from an episode of low back pain were randomized to either an individualized walking program and six physiotherapist-guided education sessions over six… read on > read on >

A class of blood pressure medications appears to also help lower seniors’ risk of developing epilepsy, a new study finds. The drugs, called angiotensin receptor blockers (ARBs), might prevent epilepsy in people at highest risk of the disease, researchers reported June 17 in the journal JAMA Neurology. “This is incredibly exciting because we don’t currently have any medicines that prevent epilepsy,” said senior researcher Dr. Kimford Meador, a professor of neurology at Stanford University School of Medicine. “I hope these initial findings lead to randomized clinical trials.” Epilepsy is most often diagnosed during childhood, but more than 1% of people older than 65 are known to develop the recurring seizures associated with the brain disorder. Stroke is the most common risk factor for developing epilepsy as a senior. About 10% of stroke survivors develop seizures within five years, researchers noted. Hardened arteries and chronic high blood pressure also boost epilepsy risk, whether or not a person has had a stroke, the researchers added. “This can be a very debilitating disorder, and it’s much more common in older adults than people realize,” Meador said in a Stanford news release. A 2022 study of more than 160,000 people in Germany found that people taking ARBs for high blood pressure had a lower risk of epilepsy, researchers said. Those drugs block receptors for angiotensin II, a protein that… read on > read on >

Folks dieting to drop pounds should consider eating a fistful of nuts here and there, a new review suggests. People who ate 1.5 to 3 ounces of almonds, peanuts, pistachios or walnuts daily as part of a calorie-cutting diet wound up losing more weight than those on the same diet without nuts, researchers said. In fact, people on “nut-enriched” diets lost an extra 3 to 16 pounds compared to folks on nut-free diets, results show. “People often avoid nuts when trying to lose weight because they think that the energy and fat content in nuts can contribute to weight gain,” said senior researcher Alison Coates, dean of research in allied health and human performance with the University of South Australia. Instead, it looks like nuts might help curb hunger more effectively. “Nuts are rich in healthy unsaturated fats, plant protein and dietary fiber, all of which play a role in promoting satiety and reducing excess calorie consumption,” Coates said in a university news release. “Nuts are associated with improved cardiovascular and metabolic health, better gut health and enhanced cognitive performance.” For the review, researchers analyzed the findings of seven randomized controlled trials involving diets that cut food intake between 240 and 1,000 calories a day. The studies lasted from a month to a year, and involved 676 people who were overweight or obese. None of… read on > read on >

Cyberbullying and sexual harassment are rampant in the world of professional video gaming and online gaming, a new study reports. Nearly 96% of 145 video game players from 14 countries said they had been targeted online in the previous year. “It’s not just an isolated incident,” said lead researcher Louise Trudgett-Klose, a doctoral student in psychology with the University of South Austrialia. “The fact that 96% of players – professional or otherwise – experienced cyberbullying in the previous 12 months suggests that toxic behaviors are prevalent in the gaming community,” Trudgett-Klose noted in a university news release. Women and professional e-sports players are the most common targets of abuse, results show. Women are targeted most often for sexual harassment in the world of gaming, particularly as they rise through the elite ranks, researchers found. Women make up 46% of the world’s 3 billion video game players, and represent 16% of e-sports competitors and content creators, researchers said in background notes. “There was a definite link between the level of professional gaming and the incidence of cyberbullying, and sexual harassment for women players,” Trudgett Klose said. “The more professional a player becomes, the more they are exposed to hostile behavior.” Gaming professionals who attracted the most fame, with a large fan base and heavy presence on social media platforms, were exposed to the worst levels of… read on > read on >

The number of people severely sickened after consuming mushroom edibles sold as Diamond Shruumz-brand chocolate bars, cones or gummies has risen, the U.S. Food and Drug Administration said Tuesday. “As of June 17, 2024, a total of 26 illnesses have been reported from 16 states,” the FDA noted in an updated advisory. That’s up from 12 cases in 8 states reported a week ago. “Twenty-five of the 26 people have reported seeking medical care; 16 have been hospitalized,” the FDA added, noting that “no deaths have been reported.” The exact cause of the illnesses isn’t clear, but the FDA said its “investigation is ongoing to determine the cause of these illnesses and the appropriate next steps.” Symptoms have included “seizures, central nervous system depression [loss of consciousness, confusion, sleepiness], agitation, abnormal heart rates, hyper/hypotension, nausea and vomiting,” the agency added. The Diamond Shruumz-brand mushroom edible products are being marketed online and at smoke/vape shops, legal CBD/THC shops and other retail outlets nationwide. The FDA is asking retailers to stop selling the products. “FDA has been in contact with the firm about a possible voluntary recall, but these discussions are still ongoing,” the agency noted. The edibles pose a special danger to kids, the FDA added.“This product may appeal to children and teenagers as it is marketed as a candy,” the FDA noted. “Parents and caregivers… read on > read on >

After a recall was issued last year for lead-tainted applesauce pouches linked to illnesses in over 500 children, the discount retailer Dollar Tree failed to remove all products from store shelves for too long, federal officials said Tuesday. In a warning letter sent to the company, the U.S. Food and Drug Administration said WanaBana apple puree products remained in stores in several states through late December, two months after Dollar Tree was first told about the recall. Officials at the Virginia-based company told the agency that it refused sales of the products at registers, but the FDA said that was “not an effective measure” because at least one child in Washington state ate a recalled fruit pouch in a store before a purchase was made. The recall effort first began in October 2023, when WanaBana recalled its fruit pouches over concerns about lead and chromium contamination. Chromium is a carcinogen, according to the U.S. Centers for Disease Control and Prevention. As a seller of the pouches, Dollar Tree was notified of the recall. However, subsequent checks of stores “revealed that you continued to offer the recalled WanaBana Apple Cinnamon Fruit Puree pouches on store shelves well after the recall was initiated, despite FDA’s numerous attempts to bring this serious issue to your attention,” the agency said in its warning letter. “Exposure to lead at the levels found… read on > read on >

Folks nearing retirement shouldn’t skip leg days at the gym, a new study advises. One year of heavy strength training preserves vital leg strength up to at least four years later, researchers found. “This study provides evidence that resistance training with heavy loads at retirement age can have long-term effects over several years,” concluded the research team led by Carl-Johan Boraxbekk, a professor of cognitive neuroscience of aging with Umea University in Sweden. For the study, researchers assigned 369 people at an average of 66 to one of three different groups. One-third lifted heavy weights three times a week for a year, while another third performed moderate intensity training with body weight or resistance bands thrice weekly. The remaining third were encouraged to maintain their usual level of physical activity. Bone, muscle strength and body fat were measured at the start of the clinical trial, then again after one, two and four years. Leg strength was preserved at the same level in the heavy weights group after four years, but not in the other two groups. Meanwhile, fat levels remained the same in the exercise groups but not in the control group, results show. All three groups experienced similar decreases in handgrip strength, lean leg mass and leg extensor power — the ability to kick a pedal as hard and as fast as possible. The… read on > read on >

As summers get hotter and hurricane seasons less predictable, more Americans now say that climate change affects their mental health, a new poll finds. In a survey conducted among more than 2,200 adults at the end of May, 53% of respondents said they believe that the effects of global warming impacts Americans’ mental health. That’s up from 48% of those questioned in a similar poll conducted in 2022, according to the poll’s sponsor, the American Psychiatric Association. “As psychiatrists, we know our mental state is not immune to these weather changes, and we also know that certain communities are disproportionately impacted,” said APA President Dr. Ramaswamy Viswanathan. “I would encourage those who feel overwhelmed to remember that there is still hope in the solutions we can adopt as individuals and on a more global scale.” It isn’t just peace of mind that’s being upset by high temperatures, wildfires, hurricanes and the like. According to the poll, 39% said that climate change is also affecting folks’ access to food, 37% said it was taking a toll on personal finances, their family (36%), housing (34%), their neighborhood (25%), their job or career (26%) or their education (24%). Age mattered: “The majority of respondents ages 18-34 said climate change impacts their mental [53%] and physical health [52%], while less than a quarter [<25%] of adults ages 65+ said… read on > read on >

Most seniors who survive a drug overdose often miss out on treatments that could help save them from a subsequent OD, a new study shows. Almost 24,000 Medicaid beneficiaries died from a follow-up overdose out of 137,000 who survived an OD in 2020, researchers say. That’s nearly one in five (17%). “People who have experienced one overdose are more likely to experience another,” said Miriam Delphin-Rittmon, assistant secretary for mental health and substance use at the U.S. Department of Health and Human Services. However, treatment can reduce their risk. The odds of dying from another OD were: 58% lower in people treated with methadone 52% lower in people treated with buprenorphine 30% lower in people treated with naloxone 75% lower in people who had access to behavioral health assessment or crisis services “We found that when survivors received gold-standard care such as medications for opioid use disorder and naloxone, the chances of dying from an overdose in the following year drop dramatically,” Delphin-Rittmon said. “In short, medications for opioid use disorder, opioid overdose reversal medications and behavioral health supports save lives.” Unfortunately, only 4% of the group received drugs like methadone and buprenorphine to treat opioid addiction, while only 6% filled a prescription for naloxone, which blunts the effect of opioids. What’s more, patients had to wait nearly two and a half months (72 days)… read on > read on >

Weekly Gravy

Look Good – Feel Good – Feed Good

A little about: Weekly Gravy

All Sauce from Weekly Gravy:

Colombian Family’s Genes Could Hold Key to Delaying Alzheimer’s

Walking May Do Wonders for Back Pain, Study Finds

Could Blood Pressure Meds Help Prevent Adult Epilepsy?

Looking for Weight Loss? Go Nuts

Cyberbullying Common in the World of Online Gaming

More Sickened After Eating Diamond Shruumz Bars, Cones and Gummy Edibles

Dollar Tree Left Recalled Apple Sauce Pouches on Store Shelves Too Long, FDA Says

Leg Workouts Around Retirement Could Keep You Mobile With Age

More Americans Worry About Climate Change’s Effect on Mental Health, Poll Finds

Too Often, Overdose Survivors Miss Out on Vital Treatments: Study