All Sauce from Weekly Gravy:

There have been 50 face transplants performed in 11 countries since the surgery was pioneered back in 2005, and long-term outcomes have been favorable, a new review finds. In total, 85% of people receiving these complex surgeries survived five years and 74% were still alive a decade after transplant completion, researchers report. When the numbers focused on deaths linked to the transplants per se, five- and ten-year survival rose to 96% and 83%, respectively. That’s significantly better than survival for other types of transplant, said the team of Finnish researchers. For example, at 10 years post-surgery, survival for liver transplants reaches 61% and for heart transplants the number is 65%, they noted. “The first 50 face transplants in the world during a period of 18 years demonstrate a promising survival rate of the grafts, exceeding several solid organ transplants,” concluded a team led by Dr. Pauliina Homsy, from the department of plastic surgery at the University of Helsinki. Her team published their report Sept. 18 in the journal JAMA Surgery. Homsy’s team collected data on all 50 face transplants conducted in 48 patients, carried out at 18 centers in 11 countries. Two of the patients required a second transplant, which in each case proved successful, the researchers noted. Nineteen patients were operated on in North America (18 in the United States), 29 in Europe, 1…  read on >  read on >

Cadmium, uranium, cobalt: These and other metals found in the environment can collect in the body and exacerbate heart disease, new research suggests. “Our findings highlight the importance of considering metal exposure as a significant risk factor for atherosclerosis and cardiovascular disease,” said study lead author Katlyn McGraw, a postdoctoral research scientist at Columbia University in New York City. “This could lead to new prevention and treatment strategies that target metal exposure,” she added in a Columbia news release. McGraw’s team found that as levels of various metals rose in people’s urine samples, so did evidence of stiffer, calcified arteries — a key component of heart disease. The research was published Sept. 18 in the Journal of the American College of Cardiology. The Columbia team looked specifically at a process called atherosclerosis, the gradual hardening of blood vessels caused by a buildup of fatty plaques. Atherosclerosis can also lead to the buildup of unhealthy calcium deposits in arteries. Are exposures to environmental toxic metals a contributor to all of this? To find out, McGraw’s team combed through a major database of more than 6,400 American middle-aged and older adults who were all free of heart disease when they joined the study between 2000 and 2002. Urine samples tracked each participants’ levels of six environmental metal already known to have links with heart disease: Cadmium, cobalt,…  read on >  read on >

Therapy dogs can help boost the spirits of health care workers in the same way they brighten the moods of hospital patients, a new study shows.  The furry, four-legged friends reduced emotional exhaustion and job stress among a small group of workers at two surgical and two intensive care units in the Midwest, researchers report. “We brought the dogs to the units and many times we had staff in tears sitting with the dogs, telling them about their day,” said lead investigator Beth Steinberg, a senior researcher with Ohio State University’s Center for Integrative Health. “For the most part, people have an affinity to a non-judgmental, warm, furry animal that can come and just sit with them and listen,” Steinberg said in a university news release. “Dogs don’t care what you look like, how you’re feeling that day; they just know that when you need them, they’re there.” Steinberg is co-founder of Buckeye Paws, a therapy dog program initially aimed at improving the mental and emotional health of staff at the Ohio State University Wexner Medical Center. Buckeye Paws launched in March 2020, shortly before the pandemic began taking its toll on overtaxed health professionals. To see whether the program is making a difference, researchers focused therapy dog sessions with a group of 64 health care workers. The group included doctors, nurses, nurse practitioners, respiratory…  read on >  read on >

Wegovy, Zepbound and other cutting-edge weight-loss drugs can be tough to get these days. They’re in short supply, and often too expensive to afford without insurance coverage. Because of these barriers, many people are doing an end-run around their doctor’s office, reaching out to potentially unreliable sources that promise to set them up with the drugs, a new survey finds. About 1 in 4 people surveyed said they would consider using an injectable weight-loss drug without consulting their doctor, Ohio State University researchers report. Their reasons for skipping the doctor include: Lower cost (18%) Not covered by insurance (15%) Unable to get a prescription from their doctor (9%) Lack of availability through a pharmacy (6%) However, unlicensed online pharmacies or dodgy telehealth sites could be risky places to turn to for these drugs, experts said. “It’s really important for those who want to lose weight to first discuss options with their doctor,” said Dr. Shengyi Mao, an internal medicine specialist with Ohio State. “It is not one-size-fits-all, and every medication can have risks and side effects,” Mao added in a university news release. “A trusted doctor can go through a patient’s medical history and current medications to assess their particular risks and benefits.” The U.S. Food and Drug Administration has issued two warnings this year about compounded semaglutide, which has caused dosing errors that resulted…  read on >  read on >

Folks who are content with what they’ve got could be less likely to suffer a heart attack or stroke, a new study suggests. “Our findings support a holistic approach to health care, where enhancing a person’s mental and emotional well-being is considered an integral part of preventing heart disease and stroke,” said senior study author Dr. Wen Sun, associate director of the Stroke Center at the University of Science and Technology of China in Hefei, China. “Health care professionals might consider including strategies to improve life satisfaction and happiness as part of routine care, such as recommending regular physical activities, social activities or stress management techniques as effective ways to enhance personal well-being,” Sun added. For the study, researchers analyzed data gathered from more than 120,000 participants in the U.K. Biobank, a large-scale medical database. Participants filled out questionnaires that assessed their well-being in terms of satisfaction with family, friendships, health, finances and general happiness. Researchers compared people’s well-being with their risk of four major heart-related diseases. Results show that people with the highest well-being scores had: A 44% lower risk of clogged arteries. A 45% lower risk of stroke. A 51% lower risk of heart failure. A 56% lower risk of heart attack. Further analysis suggested that people who feel more content tend to adopt healthier lifestyles and suffer less inflammation, researchers said. “These…  read on >  read on >

Deprivation, neglect and abuse during childhood can increase a person’s long-term risk of health problems, a new study warns. “Stress is implicated in nine of the 10 leading causes of death in the United States today,” said senior researcher Dr. George Slavich, director of the UCLA Laboratory for Stress Assessment and Research. “It’s about time we take that statistic seriously and begin screening for stress in all pediatric and adult clinics nationwide.” For the study, published in the journal Brain, Behavior and Immunity, researchers analyzed data on more than 2,100 participants in a long-range study funded by the National Institute on Aging. The team looked at different childhood traumas reported by the participants — financial distress, abuse, neglect, frequent moves, living apart from parents and receiving welfare. The participants also provided samples that allowed researchers to calculate 25 different disease biomarkers, and said whether they’d been diagnosed with 20 different major health conditions. Results showed that the risk of health problems in men and women increased with the amount of childhood stress they endured. Researchers also found that the effects of stress differed between men and women. Childhood stress tended to have greater effects on the metabolism of women than men, results show. On the other hand, emotional abuse and neglect appear to have greater health effects on men than women when it comes to…  read on >  read on >

A few cups of coffee each morning can help protect a person against heart disease, stroke and type 2 diabetes, a new study says. Drinking three cups of coffee a day — or about 200 to 300 milligrams of caffeine — lowered the risk of health problems linked to the heart or metabolism, researchers found. “The findings highlight that promoting moderate amounts of coffee or caffeine intake as a dietary habit to healthy people might have far-reaching benefits,” said lead researcher Dr. Chaofu Ke, a medical statistician with Suzhou Medical College of Soochow University in China. For the study, researchers analyzed data on more than 500,000 people ages 37 to 73 participating in the long-term U.K. Biobank research project. Out of that group, they identified more than 172,000 people who’d reported their caffeine intake, and another 188,000 who’d reported their coffee or tea consumption. The researchers compared people’s caffeine intake to whether they had developed two or more signs of cardiometabolic disease. That term relates to risk factors that can harm heart health, such as diabetes, high cholesterol, high blood pressure and excess body weight. Results showed that any level of coffee or caffeine intake lowered a person’s risk of suffering multiple health problems related to heart or metabolism. But the best results came with moderate intake of coffee or caffeine, they found. People who drank…  read on >  read on >

That plastic wrap you find around the food you eat is far from benign: A new study shows that more than 3,600 chemicals leach into food during the packaging process. Of that number, 79 chemicals are known to cause cancer, genetic mutations, and endocrine and reproductive issues, a team of international researchers reported Tuesday in the Journal of Exposure Science & Environmental Epidemiology. “Our research helps to establish the link between food contact chemicals and human exposure, highlights chemicals that are overlooked in biomonitoring studies and supports research into safer food contact materials,” lead study author Birgit Geueke, senior scientific officer at the nonprofit Food Packaging Forum, said in a news release on the study. Experts were stunned by the magnitude of the findings. “This is a staggering number and shows that food contact materials are a significant source of chemicals in humans,” Martin Wagner, a professor of biology at the Norwegian University of Science and Technology in Trondheim, told CNN. “The study is the first to systematically link the chemicals we use in materials to package and process foods to human exposure,” said Wagner, who was not involved in the research. While food packaging materials may comply with government regulations, the study shows these chemicals may not be completely safe, said senior study author Jane Muncke, managing director and chief scientific officer at the Food Packaging…  read on >  read on >

As wildfires continue to burn across parts of California, a new study finds that smoke from these blazes and other air pollution could be harming kids’ mental health. Repeated exposure to high levels of particle pollution increases kids’ risk of depression, anxiety and other mental health symptoms, researchers reported. What’s more, each additional day of exposure to unsafe air significantly boosted the likelihood that a youngster would suffer mental health problems. “We need to understand what these extreme events are doing to young people, their brains and their behavior,” said lead investigator Harry Smolker, a research associate with the University of Colorado-Boulder’s Institute of Cognitive Science. For the study, researchers analyzed data from 10,000 kids ages 9 to 11 participating in an ongoing study of brain development. Using the participants’ addresses, they calculated how many days in 2016 each kid was exposed to particle pollution levels the Environmental Protection Agency considers unsafe. Some studies have found that these airborne particles could be small enough to cross the blood-brain barrier and affect the brain. These particles have a diameter of less than 2.5 micrometers; by comparison, a human hair is about 50 micrometers in diameter. Adult hospital admissions for depression, suicide and psychosis tend to increase on high pollution days, researchers said in background notes. When pregnant women are exposed to heavy particle pollution, their children…  read on >  read on >

Brain training aimed at improving memory can ward off symptoms of Alzheimer’s disease for years, a new study claims. Seniors experienced a slower decline in their memory and thinking abilities after undergoing brain training, compared to others who didn’t get the training, researchers found. This benefit persisted for five years after the seniors got the brain training, results show. “These results are important because this kind of intervention is non-pharmacological — there are no drugs involved — and can have a significant impact on the lives of those affected,” said lead researcher Sylvie Belleville, research chair in cognitive neuroscience of aging and brain plasticity at the University of Montreal. For the study, 145 seniors with mild cognitive impairment were recruited from memory clinics in Montreal and Quebec City between 2012 and 2015. One-third of the seniors were randomly assigned to receive training in memory strategies. They worked on things like memorizing the names of people, remembering lists of items or tasks and focusing their attention to better memorize. Another third underwent training to help their overall psychological well-being, such as techniques in anger management and problem-solving. The final third received no training at all. The initial results “showed that early intervention can improve cognitive function in people at risk of Alzheimer’s disease,” Belleville said in a university news release. “We had also observed cerebral changes…  read on >  read on >